Molecular Formula | C8H6ClF3O |
Molar Mass | 210.58 |
Density | 1.416g/cm3 |
Melting Point | 57-60°C |
Boling Point | 227.1°C at 760 mmHg |
Flash Point | 110°C |
Vapor Presure | 0.0446mmHg at 25°C |
Appearance | powder to crystal |
Color | White to Almost white |
Storage Condition | Room Temprature |
Refractive Index | 1.484 |
MDL | MFCD01631469 |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R22 - Harmful if swallowed |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
HS Code | 29062990 |
Hazard Class | IRRITANT |
Packing Group | Ⅲ |
Application | 2-chloro-5-trifluoromethylbenzyl alcohol is an important chemical used in the synthesis of pharmaceuticals and pesticides. 2-chloro-5-trifluoromethylbenzyl alcohol is an intermediate of cholesterol lipid transfer protein blocker ansertrapi. |
preparation | synthesis of 2-chloro-5-trifluoromethylbenzyl alcohol (2): a thermometer was attached to a three-necked flask of 5L, with a mechanical stirrer, 2-chloro-5-trifluoromethylbenzoic acid (100g,0.45mol) was added, and 1L of tetrahydrofuran was added. Under the protection of N2, borane-tetrahydrofuran (0.9 ML, 1.5 mol) was slowly added dropwise, and the mixture was heated at reflux for h. After completion of the reaction, 6N HCl was slowly added dropwise until gas was not evolved, and 1L of water was added, followed by extraction with EtOAc(2x 1L). The organic phases were combined, dried over MgSO4, and spin-dried to give 2-chloro-5-trifluoromethylbenzylalcohol (2) as a white solid in 85% yield. For this method, the ratio of 2-chloro-5-trifluoromethylbenzoic acid: BH3.THF = 1: 2. |